The therapeutic potential of TLR ligands in spinal cord injury

Status: Ongoing


This project investigates the effects of TLR9 and TLR7 ligands on locomotor, pain and bladder dysfunction in mice sustaining a contusion injury.  The TLR ligands are delivered intrathecally.  Injury is induced by use of the Infinite Horizon Imapctor.  Locomotor function is assessed by open field activity and Catwalk.  Chronic pain is assessed by evaluating thermal hypersensitivity using the paw withdrawal and tail flick tests to a thermal stimulus.

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