Tag Archives: Robert_F_Heary

The therapeutic potential of TLR ligands in spinal cord injury

Published / by spinecenter

Status: Ongoing


Description:

This project investigates the effects of TLR9 and TLR7 ligands on locomotor, pain and bladder dysfunction in mice sustaining a contusion injury.  The TLR ligands are delivered intrathecally.  Injury is induced by use of the Infinite Horizon Imapctor.  Locomotor function is assessed by open field activity and Catwalk.  Chronic pain is assessed by evaluating thermal hypersensitivity using the paw withdrawal and tail flick tests to a thermal stimulus.

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Proteomic strategies to define new therapeutic targets in animal models of spinal cord injury and disease

Published / by spinecenter

Status: Ongoing


Description:

State-of-the art proteomic approaches are used to unravel disease mechanisms and define new targets for therapeutic interventions.

Name of Collaborator:

Hong Li, Ph.D. and colleagues-NJMS

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Etiology of multiple sclerosis using an animal model of the disease

Published / by spinecenter

Status: Ongoing


Description:

The goal of this project is to determine whether maternal immune stimulation during pregnancy influences the vulnerability of the offspring to experimental autoimmune encephalomyelitis during adulthood.

Name of Collaborator:

Nicholas Ponzio Ph.D. and colleagues – NJMS

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Role of TLR9 in central nervous system development

Published / by spinecenter

Status: Ongoing


Description:

This project investigates the behavioral and molecular alterations resulting from the genetic deletion of TLR9 during development.  TLR9 knockout mice are used as a model.  The behavioral paradigms assess motor function, sensory reactivity and learning.

Name of Collaborator:

Kevin Beck, Ph.D., Richard Servatius Ph.D and colleagues, EOVA and NJMS

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Neuron-glia interactions in the spinal cord

Published / by spinecenter

Status: Ongoing


Description:

This project investigates the cross-talk between spinal cord neurons and glia in the context of TLR activation or inhibition, using purified neuron-glia co-cultures.

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Neuroprotection in spinal cord injury and disease

Published / by spinecenter

Status: Ongoing


Description:

This project focuses on the mechanisms underlying plasma membrane calcium ATPase and collapsing response mediator protein-mediated neuronal degeneration and neuroprotection in experimental autoimmune encephalomyelitis and spinal cord injury.  A combination of in vivo models, spinal cord neuronal cultures and genetically modified mice are used.

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Modulation of the inflammatory response in spinal cord injury and disease

Published / by spinecenter

Status: Ongoing


Description:

This project defines stimuli that can promote the beneficial effects and attenuate the detrimental outcomes of inflammation in spinal cord injury and in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis.  Molecular and cellular approaches including flow cytometry, ELISA, Luminex multiplex assays, PCR arrays and quantitative RT-PCR are used.

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Early surgical decompression for the treatment of acute traumatic spinal cord injury

Published / by spinecenter

Status: Ongoing


Description:

This project involves studying the potential therapeutic benefits of surgical decompression of the spinal cord in order to prevent secondary injury and optimize the environment for neurological recovery. Motor, sensory and autonomic functions are assessed by a number of behavioral tests.  Histological approaches are used to evaluate white matter sparing and lesion volume.

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The role of plasma membrane calcium ATPase 2 (PMCA2) in the processing of nociceptive and neuropathic pain signals in the spinal cord

Published / by spinecenter

Status: Ongoing


Description:

This project investigates the contribution of PMCA2 to mechanisms underlying the processing of nociceptive and pain signals in the spinal cord dorsal horn by use of genetically modified mice, tissue culture and animal models of injury and disease.

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