Grant title: The astroglial response to spinal cord injury: modulation by a toll-like receptor 9 antagonist
Period of award: July 1, 2017 – June 30, 2020
Total amount awarded: $600,000
The studies proposed in this grant investigate the effects of a TLR9 antagonist on astrocytes at the glial scar following spinal cord injury. The modulation of astrocyte proliferation, chondroitin sulfate proteoglycan production, migration and astrocyte-elicited chemotaxis of peripheral immune cells are studied by a combination of in vivo and in vitro approaches.