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Clinical Trials

Active Clinical Trials

PCORI (Patient Centered Outcomes Research Institute - Cervical Spondylotic Myelopathy Surgical Trial (CSM-S Trial) - Enrolling (2013 to present) 

Prospective, randomized control trial, multi-center trial to compare health-related quality of life and disease-specific outcome comparing front versus back surgical approaches for patients with multi-level cervical spondylotic myelopathy. On-going trial.

Cerapedics, LLC - An Assessment of P-15 Bone Putty in Anterior Cervical Fusion with Instrumentation - Enrollment Closed (2008 to present)

This is a randomized, controlled, multi-center, prospective FDA IDE study conducted to assess the safety and effectiveness of i-FACTOR bone graft (Cerapedics, Inc. Westminster, CO) in patients treated with single level ACDF. Patient follow-up is continued 6 years post-surgery. On-going trial.

DePuy Spine, Inc. Enrollment Closed (2006 to present) - Enrollment Closed

A Multi-Center, Prospective Randomized Controlled Trial Comparing Cervical Arthroplasty to Anterior Cervical Discectomy and Fusion (ACDF) for the Treatment of Cervical Degenerative Disc Disease (DDD) (Discover)

This IDE Study compares the use of  Discover artificial cervical disc replacement to ACDF for 1 and 2 levels.

Wallace Foundation - Enrollment Closed (2010 to present) 

NEUROPOINT - Neurosurgery Patient Outcomes in Treating Spinal Disorders

Prospective Clinical Trials

InVivo Therapeutics, Inc.

Pilot Study of Clinical Safety and Feasibility of the PLGA-Poly-L-Lysine scaffold for the Treatment of Complete (AIS A) Traumatic Acute Spinal Cord Injury

Stem Cells, Inc.

A Single-Blind, Randomized, Parallel Arm, Phase II Proof-of-Concept Study of the Safety and Efficacy of HuCNS-SC Transplantation in Cervical Spinal Cord Injur

PCORI (Patient-Centered Outcomes Research Institute)

Cervical Spine Patient Outcomes Research Trial (C-SPORT) 

Selected Past Clinical Trials- Closed

 

Proneuron Biotechnologies, Inc.

A Phase II Multicenter, Randomized Controlled Study to Evaluate the Safety and Efficacy of Autologous Incubated Macrophages for the Treatment of Patients with Complete Spinal Cord Injuries

This study involves performing surgery on patients with spinal cord injuries and comparing their long-term outcomes with control spinal cord injured patients who did not undergo the surgery.

Wallace Clinical Trials Center:  Wallace Clinical Trials Award - Completed

A Multicenter Controlled Trial Comparing Dorsal to Ventral Surgery for Cervical Spondylotic Myelopathy

A prospective, observational study comparing the results of ventral versus dorsal cervical spine surgery

National Institutes of Health (NIH) – UL1 RR024146:  NIH Clinical and Translational Award

Prospective Multicenter Trial Comparing Ventral to Dorsal Surgery for Cervical Spondylotic Myelopathy

A prospective, clinical trial comparing the results of ventral versus dorsal cervical spine surgery. 

Kessler Medical Rehabilitation Research and Education Corporation [KMRREC] Resident Research Fund and Clinical Eastern Paralyzed Veterans of America [EPVA]

The Association of High-Dose Methylprednisolone and Myopathy in Acute Spinal Cord Injury Patients

This study analyzed the effects of high-dose steroid medications on muscle function following acute SCI

DePuy AcroMed, Inc.

Pedicle Screw Pullout Strength in the Thoracic Spine:  Traditional versus Lateral Placement

 

Examines biomechanical effects of different methods of stabilizing vertebra in the thoracic spine

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